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SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
USERS' SCORE
Good
Based on 1 Reviews
8.3
Supplement Facts
Serving Size: 1 Caplet
Amount Per Serving
%DV
Zinc (as Zinc Gluconate)
50 mg
455%
Top Medical Research Studies
9
Zinc benefits heart health post-cisplatin
Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats.
Significant relevance to heart protection
We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.
In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.
As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.
Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.
As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.
Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
Read More
8
Zinc supplementation improves heart health
Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling.
Effectiveness of zinc assessed
We explored the connection between zinc supplementation and heart health, particularly in the context of obesity. Our research focused on how zinc affects cardiac remodeling, a process that can lead to serious heart issues when influenced by factors like high-fat diets. In our study, obese mice were examined after being fed a high-fat diet, allowing us to observe changes in their heart structures and inflammation levels.
Notably, we found that zinc appeared to counteract some of the harmful effects associated with obesity. For instance, when zinc was administered, it helped boost the levels of metallothionein, a protein known to protect the heart. This was significant as mice lacking this protein exhibited increased heart inflammation and structural changes when exposed to high-fat diets compared to their counterparts who received adequate zinc.
Ultimately, we concluded that zinc plays a crucial role in maintaining heart health, especially in conditions of obesity. This suggests that zinc could be a useful supplement for individuals struggling with weight-related heart problems, promoting better overall heart function and reducing inflammation.
Notably, we found that zinc appeared to counteract some of the harmful effects associated with obesity. For instance, when zinc was administered, it helped boost the levels of metallothionein, a protein known to protect the heart. This was significant as mice lacking this protein exhibited increased heart inflammation and structural changes when exposed to high-fat diets compared to their counterparts who received adequate zinc.
Ultimately, we concluded that zinc plays a crucial role in maintaining heart health, especially in conditions of obesity. This suggests that zinc could be a useful supplement for individuals struggling with weight-related heart problems, promoting better overall heart function and reducing inflammation.
Read More
8
Trace minerals and heart health
Relationship between coronary artery disease with dyslipidaemia and trace mineral intake: a cross-sectional analysis of the Shika study.
Moderate relevance to heart disease
We analyzed the relationship between trace mineral intake, specifically zinc, and the risk of coronary artery disease (CAD) in middle-aged and older adults. The participants, totaling 895 residents from Shika town in Japan, were selected carefully to exclude those with a genetic predisposition to high cholesterol levels.
Our findings indicated interesting interactions between dyslipidaemia and various trace minerals like zinc, copper, and manganese. We observed that lower intakes of these minerals were notably associated with a higher occurrence of CAD among individuals with dyslipidaemia. For instance, zinc was highlighted as a significant factor, with a lower risk ratio for CAD when intake was sufficient.
While our study emphasizes the importance of trace minerals, especially zinc, in relation to heart disease, it also underlines the complexity of these relationships. The study suggests that addressing low mineral intake could be part of a strategy to manage heart disease in affected individuals. However, further research over a longer duration is essential to fully understand these dynamics and their potential impact on heart health.
Our findings indicated interesting interactions between dyslipidaemia and various trace minerals like zinc, copper, and manganese. We observed that lower intakes of these minerals were notably associated with a higher occurrence of CAD among individuals with dyslipidaemia. For instance, zinc was highlighted as a significant factor, with a lower risk ratio for CAD when intake was sufficient.
While our study emphasizes the importance of trace minerals, especially zinc, in relation to heart disease, it also underlines the complexity of these relationships. The study suggests that addressing low mineral intake could be part of a strategy to manage heart disease in affected individuals. However, further research over a longer duration is essential to fully understand these dynamics and their potential impact on heart health.
Read More
Most Useful Reviews
6.3
Boosts immunity
Zinc is essential for the body's overall health, particularly for the heart, liver, and nerves. It acts as an antioxidant that enhances immunity and plays a crucial role in managing heart disease. Additionally, it strengthens hair, and a deficiency can lead to various health issues. This product offers good quality and quantity, with beneficial ingredients.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.5
9
Zinc's role in cardiac protection
ANP Increases Zn Accumulation During Reperfusion in Ex Vivo and In Vivo Hearts.
Study emphasizes combined treatment effects
We explored the fascinating relationship between heart health, atrial natriuretic peptide (ANP), and zinc (Zn) in the context of ischemia/reperfusion (I/R) injury, a condition that occurs when blood supply returns to the heart after a period of being blocked. Our research utilized a range of models, including isolated heart experiments in rats and ANP knockout mice, along with clinical investigations involving plasma samples from 216 patients suffering from ischemia-related diseases.
During our experiments, we observed that levels of ANP significantly increased during reperfusion, which, in turn, promoted zinc accumulation in the heart tissue. This uptick in zinc led to protective effects on the heart, primarily by reducing injury during the reperfusion phase. Interestingly, when we applied a zinc chelator, we found that it negated the beneficial impacts of both ANP and zinc, highlighting the crucial role zinc plays in conjunction with ANP.
Furthermore, we discovered that ANP modulates zinc levels by downregulating a specific transporter known as ZnT8 through a pathway called PI3K signaling. While the interplay between ANP and zinc is evident, the study suggests that zinc alone's effectiveness in treating heart conditions cannot be fully isolated due to these combined effects. Overall, our findings point to a complex relationship in heart protection strategies, where both ANP and zinc play essential, interlinked roles.
During our experiments, we observed that levels of ANP significantly increased during reperfusion, which, in turn, promoted zinc accumulation in the heart tissue. This uptick in zinc led to protective effects on the heart, primarily by reducing injury during the reperfusion phase. Interestingly, when we applied a zinc chelator, we found that it negated the beneficial impacts of both ANP and zinc, highlighting the crucial role zinc plays in conjunction with ANP.
Furthermore, we discovered that ANP modulates zinc levels by downregulating a specific transporter known as ZnT8 through a pathway called PI3K signaling. While the interplay between ANP and zinc is evident, the study suggests that zinc alone's effectiveness in treating heart conditions cannot be fully isolated due to these combined effects. Overall, our findings point to a complex relationship in heart protection strategies, where both ANP and zinc play essential, interlinked roles.
Read More
9
Zinc benefits heart health post-cisplatin
Role of zinc oxide nanoparticles supplementation on alleviate side effects of cisplatin induced cardiotoxicity in rats.
Significant relevance to heart protection
We explored the potential benefits of zinc oxide nanoparticles (ZnONPs) in preventing heart damage caused by cisplatin, a powerful chemotherapy drug known for its efficacy but also for its side effects, particularly cardiotoxicity.
In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.
As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.
Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
In our study, rats were divided into several groups, including control groups and those receiving different doses of ZnONPs. We specifically looked at a range of health markers such as lipid levels, antioxidant activity, and inflammation in heart tissues to see how ZnONPs could help soften the impact of cisplatin on heart health.
As we gradually increased the dosage of ZnONPs to 50 mg/kg, we observed significant improvements across the various health parameters examined. Notably, at this optimal dose, the rats' heart health markers showed a remarkable recovery, aligning closely with those in the healthy control group. This suggests that ZnONPs effectively protect heart tissue from oxidative stress and inflammation associated with cisplatin treatment.
Overall, our findings highlight the promising role of zinc oxide nanoparticles in mitigating heart damage linked to cancer treatments, paving the way for further research in this arena.
Read More
8
Zinc supplementation improves heart health
Exacerbation by knocking-out metallothionein gene of obesity-induced cardiac remodeling is associated with the activation of CARD9 signaling.
Effectiveness of zinc assessed
We explored the connection between zinc supplementation and heart health, particularly in the context of obesity. Our research focused on how zinc affects cardiac remodeling, a process that can lead to serious heart issues when influenced by factors like high-fat diets. In our study, obese mice were examined after being fed a high-fat diet, allowing us to observe changes in their heart structures and inflammation levels.
Notably, we found that zinc appeared to counteract some of the harmful effects associated with obesity. For instance, when zinc was administered, it helped boost the levels of metallothionein, a protein known to protect the heart. This was significant as mice lacking this protein exhibited increased heart inflammation and structural changes when exposed to high-fat diets compared to their counterparts who received adequate zinc.
Ultimately, we concluded that zinc plays a crucial role in maintaining heart health, especially in conditions of obesity. This suggests that zinc could be a useful supplement for individuals struggling with weight-related heart problems, promoting better overall heart function and reducing inflammation.
Notably, we found that zinc appeared to counteract some of the harmful effects associated with obesity. For instance, when zinc was administered, it helped boost the levels of metallothionein, a protein known to protect the heart. This was significant as mice lacking this protein exhibited increased heart inflammation and structural changes when exposed to high-fat diets compared to their counterparts who received adequate zinc.
Ultimately, we concluded that zinc plays a crucial role in maintaining heart health, especially in conditions of obesity. This suggests that zinc could be a useful supplement for individuals struggling with weight-related heart problems, promoting better overall heart function and reducing inflammation.
Read More
8
Trace minerals and heart health
Relationship between coronary artery disease with dyslipidaemia and trace mineral intake: a cross-sectional analysis of the Shika study.
Moderate relevance to heart disease
We analyzed the relationship between trace mineral intake, specifically zinc, and the risk of coronary artery disease (CAD) in middle-aged and older adults. The participants, totaling 895 residents from Shika town in Japan, were selected carefully to exclude those with a genetic predisposition to high cholesterol levels.
Our findings indicated interesting interactions between dyslipidaemia and various trace minerals like zinc, copper, and manganese. We observed that lower intakes of these minerals were notably associated with a higher occurrence of CAD among individuals with dyslipidaemia. For instance, zinc was highlighted as a significant factor, with a lower risk ratio for CAD when intake was sufficient.
While our study emphasizes the importance of trace minerals, especially zinc, in relation to heart disease, it also underlines the complexity of these relationships. The study suggests that addressing low mineral intake could be part of a strategy to manage heart disease in affected individuals. However, further research over a longer duration is essential to fully understand these dynamics and their potential impact on heart health.
Our findings indicated interesting interactions between dyslipidaemia and various trace minerals like zinc, copper, and manganese. We observed that lower intakes of these minerals were notably associated with a higher occurrence of CAD among individuals with dyslipidaemia. For instance, zinc was highlighted as a significant factor, with a lower risk ratio for CAD when intake was sufficient.
While our study emphasizes the importance of trace minerals, especially zinc, in relation to heart disease, it also underlines the complexity of these relationships. The study suggests that addressing low mineral intake could be part of a strategy to manage heart disease in affected individuals. However, further research over a longer duration is essential to fully understand these dynamics and their potential impact on heart health.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Reviews
8.3
6.3
Boosts immunity
Zinc is essential for the body's overall health, particularly for the heart, liver, and nerves. It acts as an antioxidant that enhances immunity and plays a crucial role in managing heart disease. Additionally, it strengthens hair, and a deficiency can lead to various health issues. This product offers good quality and quantity, with beneficial ingredients.
Read More
